8QJI

Crystal structure of GSK3b in complex with N-(4-(5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl)pyridin-2-yl)cyclopropanecarboxamide inhibitor (TW362)

Summary for 8QJI

Entry DOI	10.2210/pdb8qji/pdb
Descriptor	Glycogen synthase kinase-3 beta, N-[4-[5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl]pyridin-2-yl]cyclopropanecarboxamide (3 entities in total)
Functional Keywords	tau phosphorylation, kinase inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41896.99
Authors	Slugocka, E.A.,Grygier, P.,Wichur, T.,Czarna, A.,Wieckowska, A. (deposition date: 2023-09-13, release date: 2024-09-04, Last modification date: 2024-09-11)
Primary citation	Goral, I.,Wichur, T.,Slugocka, E.,Grygier, P.,Gluch-Lutwin, M.,Mordyl, B.,Honkisz-Orzechowska, E.,Szalaj, N.,Godyn, J.,Panek, D.,Zareba, P.,Sarka, A.,Zmudzki, P.,Latacz, G.,Pustelny, K.,Bucki, A.,Czarna, A.,Menezes, F.,Wieckowska, A. Exploring Novel GSK-3 beta Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation. Acs Chem Neurosci, 15:3181-3201, 2024 Cited by PubMed: 39158934 DOI: 10.1021/acschemneuro.4c00365 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.02 Å)

Structure validation