8QJI

Crystal structure of GSK3b in complex with N-(4-(5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl)pyridin-2-yl)cyclopropanecarboxamide inhibitor (TW362)

8QJI の概要

• エントリーDOI: 10.2210/pdb8qji/pdb
• 分子名称: Glycogen synthase kinase-3 beta, N-[4-[5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl]pyridin-2-yl]cyclopropanecarboxamide (3 entities in total)
• 機能のキーワード: tau phosphorylation, kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41896.99

構造登録者

Slugocka, E.A.,Grygier, P.,Wichur, T.,Czarna, A.,Wieckowska, A. (登録日: 2023-09-13, 公開日: 2024-09-04, 最終更新日: 2024-09-11)

• 主引用文献: Goral, I.,Wichur, T.,Slugocka, E.,Grygier, P.,Gluch-Lutwin, M.,Mordyl, B.,Honkisz-Orzechowska, E.,Szalaj, N.,Godyn, J.,Panek, D.,Zareba, P.,Sarka, A.,Zmudzki, P.,Latacz, G.,Pustelny, K.,Bucki, A.,Czarna, A.,Menezes, F.,Wieckowska, A.; Exploring Novel GSK-3 beta Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation.; Acs Chem Neurosci, 15:3181-3201, 2024; PubMed: 39158934; DOI: 10.1021/acschemneuro.4c00365

実験手法

X-RAY DIFFRACTION (3.02 Å)