8QIC

Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors

Summary for 8QIC

• Entry DOI: 10.2210/pdb8qic/pdb
• Descriptor: Threonine--tRNA ligase, 2-oxidanyl-5-[[4-(phenylmethyl)phenyl]sulfamoyl]benzoic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: threonyl trna-synthetase, malaria, plasmodium falciparum, salicylic acid, ligase
• Biological source: Escherichia coli O8
• Total number of polymer chains: 2
• Total formula weight: 94402.00

Authors

Rodriguez, J.A.,Parisini, E. (deposition date: 2023-09-13, release date: 2024-04-10)

• Primary citation: Bobrovs, R.,Bolsakova, J.,Buitrago, J.A.R.,Varaceva, L.,Skvorcova, M.,Kanepe, I.,Rudnickiha, A.,Parisini, E.,Jirgensons, A.; Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors.; Plos One, 19:e0296995-e0296995, 2024; PubMed: 38558084; DOI: 10.1371/journal.pone.0296995

Experimental method

X-RAY DIFFRACTION (2.5 Å)