8QIC

Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors

8QIC の概要

• エントリーDOI: 10.2210/pdb8qic/pdb
• 分子名称: Threonine--tRNA ligase, 2-oxidanyl-5-[[4-(phenylmethyl)phenyl]sulfamoyl]benzoic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: threonyl trna-synthetase, malaria, plasmodium falciparum, salicylic acid, ligase
• 由来する生物種: Escherichia coli O8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94402.00

構造登録者

Rodriguez, J.A.,Parisini, E. (登録日: 2023-09-13, 公開日: 2024-04-10)

• 主引用文献: Bobrovs, R.,Bolsakova, J.,Buitrago, J.A.R.,Varaceva, L.,Skvorcova, M.,Kanepe, I.,Rudnickiha, A.,Parisini, E.,Jirgensons, A.; Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors.; Plos One, 19:e0296995-e0296995, 2024; PubMed: 38558084; DOI: 10.1371/journal.pone.0296995

実験手法

X-RAY DIFFRACTION (2.5 Å)