8QE1

Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 15

8QE1 の概要

• エントリーDOI: 10.2210/pdb8qe1/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-2, 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-6-(4-methoxyphenyl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, ... (4 entities in total)
• 機能のキーワード: s-adenosylmethionine biosynthesis, allosteric inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44757.68

構造登録者

Schimpl, M. (登録日: 2023-08-30, 公開日: 2024-03-20, 最終更新日: 2024-04-10)

• 主引用文献: Atkinson, S.J.,Bagal, S.K.,Argyrou, A.,Askin, S.,Cheung, T.,Chiarparin, E.,Coen, M.,Collie, I.T.,Dale, I.L.,De Fusco, C.,Dillman, K.,Evans, L.,Feron, L.J.,Foster, A.J.,Grondine, M.,Kantae, V.,Lamont, G.M.,Lamont, S.,Lynch, J.T.,Nilsson Lill, S.,Robb, G.R.,Saeh, J.,Schimpl, M.,Scott, J.S.,Smith, J.,Srinivasan, B.,Tentarelli, S.,Vazquez-Chantada, M.,Wagner, D.,Walsh, J.J.,Watson, D.,Williamson, B.; Development of a Series of Pyrrolopyridone MAT2A Inhibitors.; J.Med.Chem., 67:4541-4559, 2024; PubMed: 38466661; DOI: 10.1021/acs.jmedchem.3c01860

実験手法

X-RAY DIFFRACTION (1.095 Å)