8QAP
Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 2
Summary for 8QAP
Entry DOI | 10.2210/pdb8qap/pdb |
Related | 8QAL 8QAN |
Descriptor | Bromodomain-containing protein 4, 2-[4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-2~{H}-isoindol-1-yl)-1,3-thiazol-2-yl]guanidine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | four helical bundle, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15540.92 |
Authors | |
Primary citation | Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G. Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines To be published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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