8Q9R

Crystal structure of MADS-box/MEF2D N-terminal domain bound to dsDNA and HDAC9 deacetylase binding motif

Summary for 8Q9R

Entry DOI	10.2210/pdb8q9r/pdb
Descriptor	Histone deacetylase 9 (HDAC9) binding motif peptide: EVKQKLQEFLLSKS, MEF2D protein, MADS box dsDNA: AACTATTTATAAGA, ... (5 entities in total)
Functional Keywords	transcriptional regulator, transcription
Biological source	Homo sapiens More
Total number of polymer chains	10
Total formula weight	66262.18
Authors	Chinellato, M.,Carli, A.,Perin, S.,Mazzoccato, Y.,Di Giorgio, E.,Brancolini, C.,Angelini, A.,Cendron, L. (deposition date: 2023-08-20, release date: 2024-04-17)
Primary citation	Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A. Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436:168541-168541, 2024 Cited by PubMed: 38492719 DOI: 10.1016/j.jmb.2024.168541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation