8Q5L
PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand 2f: 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile
Summary for 8Q5L
Entry DOI | 10.2210/pdb8q5l/pdb |
Related | 8Q5K |
Descriptor | Transcriptional regulator MvfR, 2-[4-[(2~{S})-3-[(6-chloranyl-1-propan-2-yl-benzimidazol-2-yl)amino]-2-oxidanyl-propoxy]phenyl]ethanenitrile (3 entities in total) |
Functional Keywords | transcriptional regulator, transcription |
Biological source | Pseudomonas aeruginosa UCBPP-PA14 |
Total number of polymer chains | 1 |
Total formula weight | 24687.36 |
Authors | Markham-Lee, Z.J.,Emsley, J. (deposition date: 2023-08-09, release date: 2024-01-17, Last modification date: 2024-02-07) |
Primary citation | Soukarieh, F.,Mashabi, A.,Richardson, W.,Oton, E.V.,Romero, M.,Dubern, J.F.,Robertson, S.N.,Lucanto, S.,Markham-Lee, Z.,Sou, T.,Kukavica-Ibrulj, I.,Levesque, R.C.,Bergstrom, C.A.S.,Halliday, N.,Kellam, B.,Emsley, J.,Heeb, S.,Williams, P.,Stocks, M.J.,Camara, M. Design, Synthesis, and Evaluation of New 1 H -Benzo[ d ]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. J.Med.Chem., 67:1008-1023, 2024 Cited by PubMed: 38170170DOI: 10.1021/acs.jmedchem.3c00973 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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