8PY2

Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2

This is a non-PDB format compatible entry.

Summary for 8PY2

• Entry DOI: 10.2210/pdb8py2/pdb
• Related: 8PVY
• EMDB information: 17980 18009
• Descriptor: Lys-63-specific deubiquitinase BRCC36, BRISC complex subunit Abraxas 2, BRISC and BRCA1-A complex member 2, ... (6 entities in total)
• Functional Keywords: brisc, brcc36, deubiquitylase, inhibitor, complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 562632.87

Authors

Chandler, F.,Zeqiraj, E. (deposition date: 2023-07-24, release date: 2025-02-05)

• Primary citation: Chandler, F.,Reddy, P.,Bhutda, S.,Ross, R.,Walden, M.,Walker, K.,Cassel, J.,Prakesch, M.,Campbell, L.,Foglizzo, M.,Bell, L.,Ault, J.,Al-awar, R.,Calabrese, A.,Sicheri, F.,Del Galdo, F.,Salvino, J.,Greenberg, R.,Zeqiraj, E.; First-in-class DUB Molecular Glues and Inhibitors of Inflammation; To be published,

Experimental method

ELECTRON MICROSCOPY (3.32 Å)