8PX2

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1,3-dimethyl-5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

8PX2 の概要

• エントリーDOI: 10.2210/pdb8px2/pdb
• 分子名称: Bromodomain-containing protein 2, 1,3-dimethyl-5-[1-(oxan-4-ylmethyl)benzimidazol-2-yl]pyridin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: bromodomain inhibitor, complex, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13965.11

構造登録者

Chung, C.W. (登録日: 2023-07-22, 公開日: 2023-10-18, 最終更新日: 2023-12-27)

• 主引用文献: Bradley, E.,Fusani, L.,Chung, C.W.,Craggs, P.D.,Demont, E.H.,Humphreys, P.G.,Mitchell, D.J.,Phillipou, A.,Rioja, I.,Shah, R.R.,Wellaway, C.R.,Prinjha, R.K.,Palmer, D.S.,Kerr, W.J.,Reid, M.,Wall, I.D.,Cookson, R.; Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.; J.Med.Chem., 66:15728-15749, 2023; PubMed: 37967462; DOI: 10.1021/acs.jmedchem.3c00906

実験手法

X-RAY DIFFRACTION (1.622 Å)