8PUY

TEAD2 with a covalent inhibitor

Summary for 8PUY

• Entry DOI: 10.2210/pdb8puy/pdb
• Related: 8PUX
• Descriptor: Transcriptional enhancer factor TEF-4, ~{N}-[3-[(3-pentoxyphenyl)amino]phenyl]propanamide, MYRISTIC ACID, ... (4 entities in total)
• Functional Keywords: tead2, inhibitor, covalent, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 55533.00

Authors

Guichou, J.F.,Gelin, M.,Allemand, F. (deposition date: 2023-07-17, release date: 2023-12-13, Last modification date: 2024-01-03)

• Primary citation: Fnaiche, A.,Chan, H.C.,Paquin, A.,Gonzalez Suarez, N.,Vu, V.,Li, F.,Allali-Hassani, A.,Cao, M.A.,Szewczyk, M.M.,Bolotokova, A.,Allemand, F.,Gelin, M.,Barsyte-Lovejoy, D.,Santhakumar, V.,Vedadi, M.,Guichou, J.F.,Annabi, B.,Gagnon, A.; Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration.; Acs Med.Chem.Lett., 14:1746-1753, 2023; PubMed: 38116405; DOI: 10.1021/acsmedchemlett.3c00386

Experimental method

X-RAY DIFFRACTION (2.2 Å)