8PUX

TEAD2 with a covalent inhibitor

Summary for 8PUX

Entry DOI	10.2210/pdb8pux/pdb
Descriptor	Transcriptional enhancer factor TEF-4, MYRISTIC ACID, ~{N}-[2-[(3-pentoxyphenyl)amino]phenyl]propanamide, ... (4 entities in total)
Functional Keywords	tead2, inhibitor, covalent, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	55533.00
Authors	Guichou, J.F.,Gelin, M.,Allemand, F. (deposition date: 2023-07-17, release date: 2023-12-13, Last modification date: 2024-01-03)
Primary citation	Fnaiche, A.,Chan, H.C.,Paquin, A.,Gonzalez Suarez, N.,Vu, V.,Li, F.,Allali-Hassani, A.,Cao, M.A.,Szewczyk, M.M.,Bolotokova, A.,Allemand, F.,Gelin, M.,Barsyte-Lovejoy, D.,Santhakumar, V.,Vedadi, M.,Guichou, J.F.,Annabi, B.,Gagnon, A. Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. Acs Med.Chem.Lett., 14:1746-1753, 2023 Cited by PubMed: 38116405 DOI: 10.1021/acsmedchemlett.3c00386 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation