8PT5

ERK2 covelently bound to RU187 cyclohexenone based inhibitor

8PT5 の概要

• エントリーDOI: 10.2210/pdb8pt5/pdb
• 分子名称: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{S},3~{R})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate, ... (5 entities in total)
• 機能のキーワード: mapk kinase, mapk, inhibitor, covalent, erk2, signaling protein, michael acceptor warhead
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42615.55

構造登録者

Sok, P.,Poti, A.,Remenyi, A. (登録日: 2023-07-13, 公開日: 2024-07-24)

• 主引用文献: Sok, P.,Poti, A.,Remenyi, A.,Soos, T.,Balint, D.; Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold; To Be Published,

実験手法

X-RAY DIFFRACTION (1.95 Å)