8PSR

ERK2 covalently bound to SynthRevD-12-opt artificial peptide

8PSR の概要

• エントリーDOI: 10.2210/pdb8psr/pdb
• 分子名称: Mitogen-activated protein kinase 1, SynthRevD-12-opt, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: mapk kinase, mapk, inhibitor, covalent, erk2, michael acceptor warhead, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44871.22

構造登録者

Sok, P.,Poti, A.,Gogl, G.,Remenyi, A. (登録日: 2023-07-13, 公開日: 2024-07-24)

• 主引用文献: Sok, P.,Poti, A.,Balint, D.,Soos, T.,Remenyi, A.; Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold; To Be Published,

実験手法

X-RAY DIFFRACTION (1.85 Å)