8PSD

SARS-CoV-2 XBB 1.0 closed conformation.

8PSD の概要

• エントリーDOI: 10.2210/pdb8psd/pdb
• EMDBエントリー: 17850
• 分子名称: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• 機能のキーワード: sars-cov2, cryoem, rbd-binding, fab, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 408590.38

構造登録者

Duhoo, Y.,Lau, K. (登録日: 2023-07-13, 公開日: 2023-11-01, 最終更新日: 2023-12-06)

主引用文献

Fenwick, C.,Turelli, P.,Duhoo, Y.,Lau, K.,Herate, C.,Marlin, R.,Lamrayah, M.,Campos, J.,Esteves-Leuenberger, L.,Farina, A.,Raclot, C.,Genet, V.,Fiscalini, F.,Cesborn, J.,Perez, L.,Dereuddre-Bosquet, N.,Contreras, V.,Lheureux, K.,Relouzat, F.,Abdelnabi, R.,Leyssen, P.,Levy, Y.,Pojer, F.,Le Grand, R.,Trono, D.,Pantaleo, G.
Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.
J Infect, 87:524-537, 2023

PubMed Abstract: Due to the rapid evolution of SARS-CoV-2 to variants with reduced sensitivity to vaccine-induced humoral immunity and the near complete loss of protective efficacy of licensed therapeutic monoclonal antibodies, we isolated a potent, broad-spectrum neutralizing antibody that could potentially provide prophylactic protection to immunocompromised patient populations.

PubMed: 37852477
DOI: 10.1016/j.jinf.2023.10.008

実験手法

ELECTRON MICROSCOPY (2.9 Å)