8PQ2

XBB 1.0 RBD bound to P4J15 (Local)

Summary for 8PQ2

• Entry DOI: 10.2210/pdb8pq2/pdb
• EMDB information: 17819
• Descriptor: P4J15 Fragment Antigen-Binding Heavy Chain, P4J15 Fragment Antigen-Binding Light Chain, Spike protein S2', ... (4 entities in total)
• Functional Keywords: sars-cov2, cryoem, rbd-binding, fab, viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 47259.81

Authors

Duhoo, Y.,Lau, K. (deposition date: 2023-07-10, release date: 2023-11-01, Last modification date: 2024-11-13)

Primary citation

Fenwick, C.,Turelli, P.,Duhoo, Y.,Lau, K.,Herate, C.,Marlin, R.,Lamrayah, M.,Campos, J.,Esteves-Leuenberger, L.,Farina, A.,Raclot, C.,Genet, V.,Fiscalini, F.,Cesborn, J.,Perez, L.,Dereuddre-Bosquet, N.,Contreras, V.,Lheureux, K.,Relouzat, F.,Abdelnabi, R.,Leyssen, P.,Levy, Y.,Pojer, F.,Le Grand, R.,Trono, D.,Pantaleo, G.
Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.
J Infect, 87:524-537, 2023

PubMed Abstract: Due to the rapid evolution of SARS-CoV-2 to variants with reduced sensitivity to vaccine-induced humoral immunity and the near complete loss of protective efficacy of licensed therapeutic monoclonal antibodies, we isolated a potent, broad-spectrum neutralizing antibody that could potentially provide prophylactic protection to immunocompromised patient populations.

PubMed: 37852477
DOI: 10.1016/j.jinf.2023.10.008

Experimental method

ELECTRON MICROSCOPY (3.85 Å)