8PPZ

Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR

Summary for 8PPZ

• Entry DOI: 10.2210/pdb8ppz/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, ... (6 entities in total)
• Functional Keywords: fkbp12, mtor, kinase, complex, molecular glue, isomerase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 24390.17

Authors

Meyners, C.,Deutscher, R.C.E.,Hausch, F. (deposition date: 2023-07-10, release date: 2023-08-09, Last modification date: 2024-06-19)

• Primary citation: Meyners, C.,Deutscher, R.C.E.,Hausch, F.; Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-4vb0m

Experimental method

X-RAY DIFFRACTION (1.85 Å)