8PPZ
Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
Summary for 8PPZ
Entry DOI | 10.2210/pdb8ppz/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, ... (6 entities in total) |
Functional Keywords | fkbp12, mtor, kinase, complex, molecular glue, isomerase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 24390.17 |
Authors | Meyners, C.,Deutscher, R.C.E.,Hausch, F. (deposition date: 2023-07-10, release date: 2023-08-09, Last modification date: 2024-06-19) |
Primary citation | Meyners, C.,Deutscher, R.C.E.,Hausch, F. Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR Chemrxiv, 2023 Cited by DOI: 10.26434/chemrxiv-2023-4vb0mPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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