8PPX

Influenza A/California/07/2009(H1N1) endonuclease in complex with flavonoid-like compound

Summary for 8PPX

Entry DOI	10.2210/pdb8ppx/pdb
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	rna-dependent rna polymerase, endonuclease inhibitor, flavonoids, antivirals, viral protein
Biological source	Influenza A virus (A/California/07/2009(H1N1)) More
Total number of polymer chains	1
Total formula weight	22041.51
Authors	Radilova, K.,Brynda, J. (deposition date: 2023-07-10, release date: 2025-01-15, Last modification date: 2025-04-16)
Primary citation	Reiberger, R.,Kral, M.,Radilova, K.,Kotacka, T.,Tsalyy, A.,Majer, P.,Dracinsky, M.,Brynda, J.,Konvalinka, J.,Kozisek, M.,Machara, A. Beyond Natural Flavonoids: Exploring Bioisosterism in Design and Synthesis of Influenza Endonuclease Inhibitors Rsc Med Chem, 2025 Cited by DOI: 10.1039/D5MD00071H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation