8PPH

Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with alpha-D-glucopyranosyl 1,3,4-trisphosphate/ATP/Mn

8PPH の概要

• エントリーDOI: 10.2210/pdb8pph/pdb
• 関連するPDBエントリー: 8PP8 8PP9 8PPA 8PPB 8PPC 8PPD 8PPE 8PPF 8PPG
• 分子名称: Inositol-trisphosphate 3-kinase A, ADENOSINE-5'-TRIPHOSPHATE, alpha-D-glucopyranosyl 1,3,4-trisphosphate, ... (6 entities in total)
• 機能のキーワード: inositol polyphosphate, insp, inositol kinase, ip3k, calcium, insp3, ip3, ipk, ip3 3-k, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65971.31

構造登録者

Marquez-Monino, M.A.,Gonzalez, B. (登録日: 2023-07-07, 公開日: 2024-02-28, 最終更新日: 2024-03-27)

• 主引用文献: Marquez-Monino, M.A.,Ortega-Garcia, R.,Whitfield, H.,Riley, A.M.,Infantes, L.,Garrett, S.W.,Shipton, M.L.,Brearley, C.A.,Potter, B.V.L.,Gonzalez, B.; Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity.; Nat Commun, 15:1502-1502, 2024; PubMed: 38374076; DOI: 10.1038/s41467-024-45917-5

実験手法

X-RAY DIFFRACTION (1.7 Å)