8POS

Crystal structure of wolbachia leucyl-tRNA synthetase editing domain bound to cmpd9-AMP adduct

Summary for 8POS

• Entry DOI: 10.2210/pdb8pos/pdb
• Related: 8POQ 8POR
• Descriptor: Leucine--tRNA ligase, [(1R,3'S,5S,6R,8R)-3'-(aminomethyl)-8-(6-aminopurin-9-yl)-4'-bromanyl-7'-[3-[methyl-(phenylmethyl)amino]propoxy]spiro[2,4,7-trioxa-3$l^{4}-borabicyclo[3.3.0]octane-3,1'-3H-2,1$l^{4}-benzoxaborole]-6-yl]methyl dihydrogen phosphate, SULFATE ION, ... (4 entities in total)
• Functional Keywords: leucine trna ligase, atp binding protein, trna aminoacylation for protein translation, cytosolic reaction catalysed: atp + l-leucine + trna(leu) = amp + diphosphate + l-leucyl-trna(leu), ligase
• Biological source: Wolbachia endosymbiont strain TRS of Brugia malayi
• Total number of polymer chains: 2
• Total formula weight: 41647.00

Authors

Palencia, A.,Hoffmann, G. (deposition date: 2023-07-05, release date: 2024-06-12)

• Primary citation: Palencia, A.,Hoffmann, G.,Lukarska, M.,Clare, R.,Ward, S.,Taylor, M.A.,Ringkjobing Jensen, M.; Targeting A Microbiota Wolbachian Aminoacyl-tRNA Synthetase To Block Its Pathogenic Host; Science Advances, 2024

Experimental method

X-RAY DIFFRACTION (2.137 Å)