8PON
TEAD2 in complex with an inhibitor
Summary for 8PON
Entry DOI | 10.2210/pdb8pon/pdb |
Related | 8P29 8POJ 8POM |
Descriptor | Transcriptional enhancer factor TEF-4, MYRISTIC ACID, 4-fluoranyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid, ... (4 entities in total) |
Functional Keywords | inhibitor, tead, complex, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 55543.91 |
Authors | |
Primary citation | Fnaiche, A.,Melin, L.,Suarez, N.G.,Paquin, A.,Vu, V.,Li, F.,Allali-Hassani, A.,Bolotokova, A.,Allemand, F.,Gelin, M.,Cotelle, P.,Woo, S.,LaPlante, S.R.,Barsyte-Lovejoy, D.,Santhakumar, V.,Vedadi, M.,Guichou, J.F.,Annabi, B.,Gagnon, A. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg.Med.Chem.Lett., 95:129488-129488, 2023 Cited by PubMed: 37770003DOI: 10.1016/j.bmcl.2023.129488 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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