8PND
The ES3 intermediate of hydroxymethylbilane synthase R167Q variant
Summary for 8PND
Entry DOI | 10.2210/pdb8pnd/pdb |
Related | 7AAJ 7AAK |
Descriptor | Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hydroxymethylbilane synthase, hmbs, porphobilinogen deaminase, pbgd, hydroxymethylbilane, porphobilinogen, haem biosynthesis, porphyria, acute intermittent porphyria, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 82581.81 |
Authors | Saeter, M.C.,Bustad, H.J.,Laitaoja, M.,Janis, J.,Martinez, A.,Aarsand, A.K.,Kallio, J.P. (deposition date: 2023-06-30, release date: 2023-11-01, Last modification date: 2024-02-14) |
Primary citation | Bustad, H.J.,Christie, M.S.,Laitaoja, M.,Aarsand, A.K.,Martinez, A.,Janis, J.,Kallio, J.P. One ring closer to a closure: the crystal structure of the ES 3 hydroxymethylbilane synthase intermediate. Febs J., 291:510-526, 2024 Cited by PubMed: 37863644DOI: 10.1111/febs.16982 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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