8PN9
Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1
Summary for 8PN9
Entry DOI | 10.2210/pdb8pn9/pdb |
EMDB information | 17779 |
Descriptor | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (18 entities in total) |
Functional Keywords | n-glycosylation, ost-a complex, ngi-1 inhibitor, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 321362.22 |
Authors | |
Primary citation | Lampson, B.L.,Ramirez, A.S.,Baro, M.,He, L.,Hegde, M.,Koduri, V.,Pfaff, J.L.,Hanna, R.E.,Kowal, J.,Shirole, N.H.,He, Y.,Doench, J.G.,Contessa, J.N.,Locher, K.P.,Kaelin Jr., W.G. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B. Cell, 187:2209-2223.e16, 2024 Cited by PubMed: 38670073DOI: 10.1016/j.cell.2024.03.022 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.61 Å) |
Structure validation
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