8PN9
Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1
8PN9 の概要
エントリーDOI | 10.2210/pdb8pn9/pdb |
EMDBエントリー | 17779 |
分子名称 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (18 entities in total) |
機能のキーワード | n-glycosylation, ost-a complex, ngi-1 inhibitor, transferase |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 321362.22 |
構造登録者 | |
主引用文献 | Lampson, B.L.,Ramirez, A.S.,Baro, M.,He, L.,Hegde, M.,Koduri, V.,Pfaff, J.L.,Hanna, R.E.,Kowal, J.,Shirole, N.H.,He, Y.,Doench, J.G.,Contessa, J.N.,Locher, K.P.,Kaelin Jr., W.G. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B. Cell, 187:2209-2223.e16, 2024 Cited by PubMed: 38670073DOI: 10.1016/j.cell.2024.03.022 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (3.61 Å) |
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