9TPA

The ERAD misfolded glycoprotein checkpoint complex from Chaetomium thermophilum (EDEM:PDI heterodimer).

Replaces:  8PKO

Summary for 9TPA

• Entry DOI: 10.2210/pdb9tpa/pdb
• EMDB information: 56105
• Descriptor: Green fluorescent protein,alpha-1,2-Mannosidase, Protein disulfide-isomerase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: mannosidase, disulfide isomerase, glycoprotein degradation, erad, misfolding, oxidoreductase, hydrolase
• Biological source: Aequorea victoria (Water jellyfish, Mesonema victoria); More
• Total number of polymer chains: 2
• Total formula weight: 201061.03

Authors

Roversi, P.,Hitchman, C.J.,Lia, A.,Bayo, Y.,Gooptu, B. (deposition date: 2025-12-17, release date: 2026-07-01)

• Primary citation: Hitchman, C.J.,Lia, A.,Chiritoiu, G.N.,Munteanu, C.V.A.,Ortigosa, J.R.,Ghenea, S.,Savva, C.,Wada, I.,De Benedictis, M.,Tax, G.,Bayo, Y.,Crescioli, I.,Alonzi, D.L.,Quigley, A.,Modenutti, C.P.,Petrescu, S.M.,Santino, A.,Gooptu, B.,Hosokawa, N.,Roversi, P.; Structure and function of the EDEM:PDI ERAD checkpoint complex; Biorxiv, 2025; DOI: 10.1101/2025.01.29.635535

Experimental method

ELECTRON MICROSCOPY (2.6 Å)