8PK8

Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (persulfide on ISCU2)

8PK8 の概要

• エントリーDOI: 10.2210/pdb8pk8/pdb
• EMDBエントリー: 17732
• 分子名称: Cysteine desulfurase, LYR motif-containing protein 4, Acyl carrier protein, ... (9 entities in total)
• 機能のキーワード: cysteine desulfurase, fes biosynthesis, fes biogenesis, mitochondria, friedreich's ataxia, persulfide, frataxin, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 98200.09

構造登録者

Steinhilper, R.,Murphy, B.J. (登録日: 2023-06-26, 公開日: 2024-05-01)

• 主引用文献: Schulz, V.,Steinhilper, R.,Oltmanns, J.,Freibert, S.A.,Krapoth, N.,Linne, U.,Welsch, S.,Hoock, M.H.,Schunemann, V.,Murphy, B.J.,Lill, R.; Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.; Nat Commun, 15:3269-3269, 2024; PubMed: 38627381; DOI: 10.1038/s41467-024-47310-8

実験手法

ELECTRON MICROSCOPY (2.49 Å)