8PJG

F11 TCR in complex with Human Leukocyte Antigen class II allotype DR1 presenting P11T->R modified influenza A virus haemagglutinin (HA)306-318 PKYVKQNTLKLAR

8PJG の概要

• エントリーDOI: 10.2210/pdb8pjg/pdb
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1 beta chain, Hemagglutinin HA2 chain, ... (8 entities in total)
• 機能のキーワード: hla-ii, hla-dr, hla-dr1, human leukocyte antigen, major histocompatibility complex, major histocompatibility complex class 2, influenza a virus, flu, haemagglutinin, ha, infection, vaccine, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 96610.40

構造登録者

MacLachlan, B.J.,Wall, A.,Greenshields-Watson, A.L.,Cole, D.K.,Rizkallah, P.J.,Godkin, A.J. (登録日: 2023-06-23, 公開日: 2024-06-19)

• 主引用文献: Hulin-Curtis, S.,Geary, J.K.,MacLachlan, B.J.,Altmann, D.M.,Baillon, L.,Cole, D.K.,Greenshields-Watson, A.,Hesketh, S.J.,Humphreys, I.R.,Jones, I.M.,Lauder, S.N.,Mason, G.H.,Smart, K.,Scourfield, D.O.,Scott, J.,Sukhova, K.,Stanton, R.J.,Wall, A.,Rizkallah, P.J.,Barclay, W.S.,Gallimore, A.,Godkin, A.; A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4 + T cell activation.; Cell Rep, 43:114259-114259, 2024; PubMed: 38819988; DOI: 10.1016/j.celrep.2024.114259

実験手法

X-RAY DIFFRACTION (1.83 Å)