8PIE
Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010
Summary for 8PIE
Entry DOI | 10.2210/pdb8pie/pdb |
Descriptor | Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 120130.84 |
Authors | Feracci, M.,Chazot, A.,Ferron, F.,Alvarez, K.,Canard, B. (deposition date: 2023-06-21, release date: 2024-07-31) |
Primary citation | Chazot, A.,Zimberger, C.,Feracci, M.,Moussa, A.,Good, S.,Sommadossi, J.P.,Alvarez, K.,Ferron, F.,Canard, B. The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution Plos Biol., 2024 Cited by DOI: 10.1371/journal.pbio.3002743PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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