8PIE

Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010

Summary for 8PIE

• Entry DOI: 10.2210/pdb8pie/pdb
• Descriptor: Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 120130.84

Authors

Feracci, M.,Chazot, A.,Ferron, F.,Alvarez, K.,Canard, B. (deposition date: 2023-06-21, release date: 2024-07-31)

• Primary citation: Chazot, A.,Zimberger, C.,Feracci, M.,Moussa, A.,Good, S.,Sommadossi, J.P.,Alvarez, K.,Ferron, F.,Canard, B.; The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution; Plos Biol., 2024; DOI: 10.1371/journal.pbio.3002743

Experimental method

X-RAY DIFFRACTION (1.9 Å)