8PIE

Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010

8PIE の概要

• エントリーDOI: 10.2210/pdb8pie/pdb
• 分子名称: Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 120130.84

構造登録者

Feracci, M.,Chazot, A.,Ferron, F.,Alvarez, K.,Canard, B. (登録日: 2023-06-21, 公開日: 2024-07-31)

• 主引用文献: Chazot, A.,Zimberger, C.,Feracci, M.,Moussa, A.,Good, S.,Sommadossi, J.P.,Alvarez, K.,Ferron, F.,Canard, B.; The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution; Plos Biol., 2024; DOI: 10.1371/journal.pbio.3002743

実験手法

X-RAY DIFFRACTION (1.9 Å)