8PI9

DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A)

Summary for 8PI9

• Entry DOI: 10.2210/pdb8pi9/pdb
• Descriptor: Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha (3 entities in total)
• Functional Keywords: transcription factor, dna binding protein, gene transcription, hnf-1a, hnf4a, mody
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 58634.90

Authors

Kind, L.,Myllykoski, M.,Raasakka, A.,Kursula, P. (deposition date: 2023-06-21, release date: 2024-06-19)

• Primary citation: Kind, L.,Molnes, J.,Tjora, E.,Raasakka, A.,Myllykoski, M.,Colclough, K.,Saint-Martin, C.,Adelfalk, C.,Dusatkova, P.,Pruhova, S.,Valtonen-Andre, C.,Bellanne-Chantelot, C.,Arnesen, T.,Kursula, P.,Njolstad, P.R.; Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.; JCI Insight, 9:-, 2024; PubMed: 38855865; DOI: 10.1172/jci.insight.175278

Experimental method

X-RAY DIFFRACTION (2.8 Å)