8PEQ

Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8)

Summary for 8PEQ

• Entry DOI: 10.2210/pdb8peq/pdb
• Descriptor: Fibronectin, Affilin variant Af2, SULFATE ION, ... (4 entities in total)
• Functional Keywords: extra domain b, edb, oncofetal fibronectin, ubiquitin, diubiqutin, affilin, beta strand register shift, strand slippage, scaffold, artificial binding protein, plasticity, directed evolution, de novo protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 141905.20

Authors

Parthier, C.,Katzschmann, A.,Fiedler, E.,Haupts, U.,Reimann, A. (deposition date: 2023-06-14, release date: 2024-06-26, Last modification date: 2024-08-14)

• Primary citation: Katzschmann, A.,Haupts, U.,Reimann, A.,Settele, F.,Gloser-Braunig, M.,Fiedler, E.,Parthier, C.; Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by beta-strand slippage.; Commun Biol, 7:907-907, 2024; PubMed: 39068227; DOI: 10.1038/s42003-024-06569-9

Experimental method