8PEQ

Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8)

8PEQ の概要

• エントリーDOI: 10.2210/pdb8peq/pdb
• 分子名称: Fibronectin, Affilin variant Af2, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: extra domain b, edb, oncofetal fibronectin, ubiquitin, diubiqutin, affilin, beta strand register shift, strand slippage, scaffold, artificial binding protein, plasticity, directed evolution, de novo protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 141905.20

構造登録者

Parthier, C.,Katzschmann, A.,Fiedler, E.,Haupts, U.,Reimann, A. (登録日: 2023-06-14, 公開日: 2024-06-26, 最終更新日: 2024-08-14)

• 主引用文献: Katzschmann, A.,Haupts, U.,Reimann, A.,Settele, F.,Gloser-Braunig, M.,Fiedler, E.,Parthier, C.; Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by beta-strand slippage.; Commun Biol, 7:907-907, 2024; PubMed: 39068227; DOI: 10.1038/s42003-024-06569-9

実験手法

X-RAY DIFFRACTION (2.32 Å)