8PEA

OXA-48_F72L. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

Summary for 8PEA

• Entry DOI: 10.2210/pdb8pea/pdb
• Descriptor: Beta-lactamase, CHLORIDE ION (3 entities in total)
• Functional Keywords: protein evolution. antibiotic resistance. oxa-48., hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 60760.87

Authors

Leiros, H.-K.S.,Frohlich, C. (deposition date: 2023-06-13, release date: 2024-02-14, Last modification date: 2024-06-12)

• Primary citation: Frohlich, C.,Bunzel, H.A.,Buda, K.,Mulholland, A.J.,van der Kamp, M.W.,Johnsen, P.J.,Leiros, H.S.,Tokuriki, N.; Epistasis arises from shifting the rate-limiting step during enzyme evolution of a beta-lactamase.; Nat Catal, 7:499-509, 2024; PubMed: 38828429; DOI: 10.1038/s41929-024-01117-4

Experimental method

X-RAY DIFFRACTION (1.97 Å)