8PE1

Crystal structure of Gel4 in complex with Nanobody 4

Summary for 8PE1

Entry DOI	10.2210/pdb8pe1/pdb
Descriptor	1,3-beta-glucanosyltransferase, Nanobody 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	transglycosylase, b-1, 3-glucan, nanobodies, fungal diseases, transferase
Biological source	Aspergillus fumigatus Af293 More
Total number of polymer chains	4
Total formula weight	131934.49
Authors	Macias-Leon, J.,Redrado-Hernandez, S.,Castro-Lopez, J.,Sanz, A.B.,Arias, M.,Farkas, V.,Vincke, C.,Muyldermans, S.,Pardo, J.,Arroyo, J.,Galvez, E.,Hurtado-Guerrero, R. (deposition date: 2023-06-13, release date: 2024-06-19, Last modification date: 2024-06-26)
Primary citation	Redrado-Hernandez, S.,Macias-Leon, J.,Castro-Lopez, J.,Sanz, A.B.,Dolader, E.,Arias, M.,Gonzalez-Ramirez, A.M.,Sanchez-Navarro, D.,Petryk, Y.,Farkas, V.,Vincke, C.,Muyldermans, S.,Garcia-Barbazan, I.,Del Agua, C.,Zaragoza, O.,Arroyo, J.,Pardo, J.,Galvez, E.,Hurtado-Guerrero, R. Broad protection against invasive fungal disease from a nanobody targeting the active site of fungal b-1,3-glucanosyltransferases. Angew.Chem.Int.Ed.Engl., :e202405823-e202405823, 2024 Cited by PubMed: 38856634 DOI: 10.1002/anie.202405823 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation