8PDI

The phosphatase and C2 domains of SHIP1 with covalent Z1763271112

Summary for 8PDI

Entry DOI	10.2210/pdb8pdi/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, (5-phenyl-1,3,4-thiadiazol-2-yl)methanimine, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	ligand, phoshphatase, c2, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	53301.21
Authors	Bradshaw, W.J.,Moreira, T.,Pascoa, T.C.,Bountra, C.,Chalk, R.,von Delft, F.,Brennan, P.E.,Gileadi, O. (deposition date: 2023-06-12, release date: 2023-07-26, Last modification date: 2024-04-17)
Primary citation	Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O. Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2. Structure, 32:453-, 2024 Cited by PubMed: 38309262 DOI: 10.1016/j.str.2024.01.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation