8PBI
Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate
Summary for 8PBI
Entry DOI | 10.2210/pdb8pbi/pdb |
Related | 8PBE 8PBG 8PBH 8PBJ 8PBK 8PBM 8PBN 8PBP 8PBQ 8PBR 8PBS 8PBT 8PBU |
Descriptor | CAD protein, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | nucleotide metabolism, de novo pyrimidine synthesis, cad disease, multienzymatic protein, zinc, carboxylated lysine, biosynthetic protein, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40108.34 |
Authors | del Cano-Ochoa, F.,Ramon-Maiques, S. (deposition date: 2023-06-09, release date: 2023-11-01, Last modification date: 2023-11-22) |
Primary citation | Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46:1170-1185, 2023 Cited by PubMed: 37540500DOI: 10.1002/jimd.12667 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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