Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8P9I

Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB462

Summary for 8P9I
Entry DOI10.2210/pdb8p9i/pdb
DescriptorBromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, epigenetic drugs, inhibitor, cancer therapy, gene regulation
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight31660.36
Authors
Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-06, release date: 2023-07-05)
Primary citationBalourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC)
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB462
to be published,
Experimental method
X-RAY DIFFRACTION (1.23 Å)
Structure validation

221051

건을2024-06-12부터공개중

PDB statisticsPDBj update infoContact PDBjnumon