8P9E
Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11
Summary for 8P9E
Entry DOI | 10.2210/pdb8p9e/pdb |
Descriptor | Isoform 2 of Tumor protein 63, Tumor protein p73, Darpin 1810 F11, ... (5 entities in total) |
Functional Keywords | p63, p73, tetramerization domain, darpin, heterotetramer, structural genomics, structural genomics consortium, sgc, dna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 30380.22 |
Authors | Chaikuad, A.,Strubel, A.,Doetsch, V.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-05, release date: 2023-11-08, Last modification date: 2023-11-15) |
Primary citation | Strubel, A.,Munick, P.,Hartmann, O.,Chaikuad, A.,Dreier, B.,Schaefer, J.V.,Gebel, J.,Osterburg, C.,Tuppi, M.,Schafer, B.,Buck, V.,Rosenfeldt, M.,Knapp, S.,Pluckthun, A.,Diefenbacher, M.E.,Dotsch, V. DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell Death Dis, 14:674-674, 2023 Cited by PubMed: 37828008DOI: 10.1038/s41419-023-06213-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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