8P9D

Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 A2

8P9D の概要

• エントリーDOI: 10.2210/pdb8p9d/pdb
• 分子名称: Tumor protein 63, Tumor protein p73, Darpin 1810 A2, ... (4 entities in total)
• 機能のキーワード: p63, p73, tetramerization domain, darpin, heterotetramer, structural genomics, structural genomics consortium, sgc, dna binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 53278.14

構造登録者

Chaikuad, A.,Strubel, A.,Doetsch, V.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2023-06-05, 公開日: 2023-11-08, 最終更新日: 2023-11-15)

• 主引用文献: Strubel, A.,Munick, P.,Hartmann, O.,Chaikuad, A.,Dreier, B.,Schaefer, J.V.,Gebel, J.,Osterburg, C.,Tuppi, M.,Schafer, B.,Buck, V.,Rosenfeldt, M.,Knapp, S.,Pluckthun, A.,Diefenbacher, M.E.,Dotsch, V.; DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.; Cell Death Dis, 14:674-674, 2023; PubMed: 37828008; DOI: 10.1038/s41419-023-06213-0

実験手法

X-RAY DIFFRACTION (2.7 Å)