8P8J
Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2
Summary for 8P8J
Entry DOI | 10.2210/pdb8p8j/pdb |
EMDB information | 17547 |
Descriptor | ATP-binding cassette sub-family G member 2, 5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, ... (5 entities in total) |
Functional Keywords | membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 253792.55 |
Authors | Irobalieva, R.N.,Manolaridis, I.,Jackson, S.M.,Ni, D.,Pardon, E.,Stahlberg, H.,Steyaert, J.,Locher, K.P. (deposition date: 2023-06-01, release date: 2023-08-30, Last modification date: 2024-10-16) |
Primary citation | Irobalieva, R.N.,Manolaridis, I.,Jackson, S.M.,Ni, D.,Pardon, E.,Stahlberg, H.,Steyaert, J.,Locher, K.P. Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies. J.Mol.Biol., 435:168234-168234, 2023 Cited by PubMed: 37597690DOI: 10.1016/j.jmb.2023.168234 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.49 Å) |
Structure validation
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