8P7G

Structural characterization of PHOX2B and its DNA interactions shed lights into the molecular basis of the + 7Ala variant pathogenicity in CCHS

8P7G の概要

• エントリーDOI: 10.2210/pdb8p7g/pdb
• NMR情報: BMRB: 34822
• 分子名称: Paired mesoderm homeobox protein 2B (1 entity in total)
• 機能のキーワード: transcription factor, homeodomain, congenital central hypoventilation syndrome, polyala expansions, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7741.80

構造登録者

Russo, L.,Diana, D.,Fattorusso, R. (登録日: 2023-05-30, 公開日: 2024-05-15, 最終更新日: 2024-06-26)

• 主引用文献: Diana, D.,Pirone, L.,Russo, L.,D'Abrosca, G.,Madheswaran, M.,Benfante, R.,Di Lascio, S.,Caldinelli, L.,Fornasari, D.,Acconcia, C.,Corvino, A.,Ventserova, N.,Pollegioni, L.,Isernia, C.,Di Gaetano, S.,Malgieri, G.,Pedone, E.M.,Fattorusso, R.; Structural characterization of PHOX2B and its DNA interaction shed light on the molecular basis of the +7Ala variant pathogenicity in CCHS.; Chem Sci, 15:8858-8872, 2024; PubMed: 38873078; DOI: 10.1039/d3sc06427a

実験手法

SOLUTION NMR