8P41

Crystal structure of glucocerebrosidase in complex with allosteric activator

8P41 の概要

• エントリーDOI: 10.2210/pdb8p41/pdb
• 分子名称: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: activator, lysosome, glycolipid metabolism, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114406.55

構造登録者

Schulze, M.-S. (登録日: 2023-05-18, 公開日: 2024-03-06, 最終更新日: 2024-05-01)

• 主引用文献: Schulze, M.E.D.,Scholz, D.,Jnoff, E.,Hall, A.,Melin, J.,Sands, Z.A.,Rodriguez, E.,Andre, V.M.; Identification of ss-Glucocerebrosidase Activators for Glucosylceramide hydrolysis.; Chemmedchem, 19:e202300548-e202300548, 2024; PubMed: 38381042; DOI: 10.1002/cmdc.202300548

実験手法

X-RAY DIFFRACTION (1.83 Å)