8P1V
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound 2
This is a non-PDB format compatible entry.
Summary for 8P1V
Entry DOI | 10.2210/pdb8p1v/pdb |
Descriptor | S-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, 6-cyclopropyl-~{N}-(2-methylindazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide, ... (6 entities in total) |
Functional Keywords | methionine adenosyltransferase, s-adenosylmethionine synthase isoform 2 type-2, sam, allosteric inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 46866.64 |
Authors | |
Primary citation | Kalliokoski, T.,Kettunen, H.,Kumpulainen, E.,Kettunen, E.,Thieulin-Pardo, G.,Neumann, L.,Thomsen, M.,Paul, R.,Malyutina, A.,Georgiadou, M. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94:129450-129450, 2023 Cited by PubMed: 37591318DOI: 10.1016/j.bmcl.2023.129450 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
Download full validation report