8P1I

Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution

Summary for 8P1I

• Entry DOI: 10.2210/pdb8p1i/pdb
• EMDB information: 17350
• Descriptor: Efflux pump membrane transporter, 3-chloranyl-2,6-di(piperazin-4-ium-1-yl)quinoline, [(2~{R})-1-[[(2~{R})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-undecanoyloxy-propan-2-yl] tricosanoate, ... (4 entities in total)
• Functional Keywords: efflux pump inhibitor, transmembrane binding, antibiotic resistance, transport protein
• Biological source: Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940
• Total number of polymer chains: 3
• Total formula weight: 345549.79

Authors

Boernsen, C.,Mueller, R.T.,Pos, K.M.,Frangakis, A.S. (deposition date: 2023-05-12, release date: 2024-01-17, Last modification date: 2024-01-31)

• Primary citation: Vieira Da Cruz, A.,Jimenez-Castellanos, J.C.,Bornsen, C.,Van Maele, L.,Compagne, N.,Pradel, E.,Muller, R.T.,Meurillon, V.,Soulard, D.,Piveteau, C.,Biela, A.,Dumont, J.,Leroux, F.,Deprez, B.,Willand, N.,Pos, K.M.,Frangakis, A.S.,Hartkoorn, R.C.,Flipo, M.; Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.; Embo Mol Med, 16:93-111, 2024; PubMed: 38177534; DOI: 10.1038/s44321-023-00007-9

Experimental method

ELECTRON MICROSCOPY (2.97 Å)