8P0I
Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor
Summary for 8P0I
Entry DOI | 10.2210/pdb8p0i/pdb |
Descriptor | Leucyl-cystinyl aminopeptidase, pregnancy serum form, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | insulin regulated aminopeptidase, irap, hsplap, antigen presentation, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 209772.55 |
Authors | |
Primary citation | Mpakali, A.,Georgaki, G.,Buson, A.,Findlay, A.D.,Foot, J.S.,Mauvais, F.X.,van Endert, P.,Giastas, P.,Hamprecht, D.W.,Stratikos, E. Stabilization of the open conformation omicron f insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor. Protein Sci., 33:e5151-e5151, 2024 Cited by PubMed: 39167040DOI: 10.1002/pro.5151 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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