8P07

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((3-(4H-1,2,4-triazol-4-yl)phenyl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

8P07 の概要

• エントリーDOI: 10.2210/pdb8p07/pdb
• 分子名称: Casein kinase II subunit alpha, SULFATE ION, 7-(cyclopropylamino)-5-[[3-(1,2,4-triazol-4-yl)phenyl]amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, ... (5 entities in total)
• 機能のキーワード: kinase, ck2, typi inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82771.73

構造登録者

Kraemer, A.,Ong, H.W.,Yang, X.,Bown, J.W.,Chang, E.,Willson, T.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2023-05-09, 公開日: 2023-05-17, 最終更新日: 2024-07-31)

• 主引用文献: Ong, H.W.,Yang, X.,Smith, J.L.,Dickmander, R.J.,Brown, J.W.,Havener, T.M.,Taft-Benz, S.,Howell, S.,Sanders, M.K.,Capener, J.L.,Counago, R.M.,Chang, E.,Kramer, A.,Moorman, N.J.,Heise, M.,Axtman, A.D.,Drewry, D.H.,Willson, T.M.; More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting beta-Coronavirus Replication.; J.Med.Chem., 2024; PubMed: 38959455; DOI: 10.1021/acs.jmedchem.4c00962

実験手法

X-RAY DIFFRACTION (2.4 Å)