8OYH

X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-Can-Tle-Can-6-(aminomethyl)-3-amino-isoindol

8OYH の概要

• エントリーDOI: 10.2210/pdb8oyh/pdb
• 分子名称: Furin, Guanidinomethyl-Phac-Can-Tle-Can-6-(aminomethyl)-3-amino-isoindol, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: furin, proprotein convertase subtilisin/kexin type 3, pcsk3, sars-cov-2, inhibitor, protease, complex, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53274.14

構造登録者

Dahms, S.O.,Brandstetter, H. (登録日: 2023-05-04, 公開日: 2024-03-13, 最終更新日: 2024-05-15)

• 主引用文献: Lange, R.W.,Bloch, K.,Heindl, M.R.,Wollenhaupt, J.,Weiss, M.S.,Brandstetter, H.,Klebe, G.,Falcone, F.H.,Bottcher-Friebertshauser, E.,Dahms, S.O.,Steinmetzer, T.; Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.; Chemmedchem, 19:e202400057-e202400057, 2024; PubMed: 38385828; DOI: 10.1002/cmdc.202400057

実験手法

X-RAY DIFFRACTION (1.8 Å)