8OY2

Human cyclin-dependent kinase 2 in complex with inhibitor HB-29260

Summary for 8OY2

Entry DOI	10.2210/pdb8oy2/pdb
Descriptor	Cyclin-dependent kinase 2, (1S,2S,11aS)-1-methoxy-1,4,7,10-tetramethyl-2,9-bis(oxidanyl)-2,11a-dihydrobenzo[b][1,4]benzodioxepine-3,6-dione, GLYCEROL, ... (4 entities in total)
Functional Keywords	inhibitor, kinase, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34545.06
Authors	Kordes, S.,Harvey, C.J.B. (deposition date: 2023-05-03, release date: 2023-11-29, Last modification date: 2023-12-06)
Primary citation	Dunbar, K.L.,Perlatti, B.,Liu, N.,Cornelius, A.,Mummau, D.,Chiang, Y.M.,Hon, L.,Nimavat, M.,Pallas, J.,Kordes, S.,Ng, H.L.,Harvey, C.J.B. Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases. Proc.Natl.Acad.Sci.USA, 120:e2310522120-e2310522120, 2023 Cited by PubMed: 37983497 DOI: 10.1073/pnas.2310522120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.618 Å)

Structure validation